Molecular “Brake” Prevents Excessive Inflammation
Source: UCSanDiego Health
Researchers at University of California, San Diego School of Medicine have discovered that a protein known as p62 acts as a molecular brake to keep inflammation in check and avoid collateral damage. The mouse study is published February 25 in Cell and was funded in part by the Alliance for Lupus Research.
“In addition to explaining how our bodies can turn off inflammation when it’s no longer needed, these findings could have important implications for many age-related diseases,” said Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology at UC San Diego School of Medicine. Karin led the study with Zhenyu Zhong, PhD, a postdoctoral researcher in his lab, and collaborators at Sanford Burnham Prebys Medical Discovery Institute.
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